ENdb-Search-Detail

About Enhancer

Enhancer ID:	E_01_0039
Species:	human
Position :	chr16:86507790-86509790
Biosample name:
Experiment class :	High+Lowthroughput
Enhancer type:	Enhancer
Disease:	Gastrointestinal stromal tumor
Pubmed ID:	29162563
Enhancer experiment:	siRNA Transfection,qRT-PCR,ChIP,ChIP-qPCR,ATAC-seq,ChIP-seq
Enhancer experiment description:	We uncover that FOXF1 defi nes the core-regulatory circuitry in GIST through both direct transcriptional regulation and pioneer factor function.

Target gene :	--
Strong evidence:	qRT-PCR,qPCR,ChIP,3C
Less strong evidence:	RNA-Seq
Target gene experiment description:	We uncover that FOXF1 defi nes the core-regulatory circuitry in GIST through both direct transcriptional regulation and pioneer factor function.;Here, we uncover that in gastrointestinal stromal tumor (GIST), the forkhead family member FOXF1 directly controls the transcription of two master regulators, KIT and ETV1, both required for GIST precursor-interstitial cells of Cajal lineage specifi cation and GIST tumorigenesis;Here, we uncover that in gastrointestinal stromal tumor (GIST), the forkhead family member FOXF1 directly controls the transcription of two master regulators, KIT and ETV1, both required for GIST precursor-interstitial cells of Cajal lineage specifi cation and GIST tumorigenesis

TF name :	FOXF1ETV1KIT
TF experiment:	siRNA Transfection,qRT-PCR,ChIP,ChIP-qPCR,ATAC-seq,ChIP-seq
TF experiment description:	We uncover that FOXF1 defi nes the core-regulatory circuitry in GIST through both direct transcriptional regulation and pioneer factor function.;Here, we uncover that in gastrointestinal stromal tumor (GIST), the forkhead family member FOXF1 directly controls the transcription of two master regulators, KIT and ETV1, both required for GIST precursor-interstitial cells of Cajal lineage specifi cation and GIST tumorigenesis;Here, we uncover that in gastrointestinal stromal tumor (GIST), the forkhead family member FOXF1 directly controls the transcription of two master regulators, KIT and ETV1, both required for GIST precursor-interstitial cells of Cajal lineage specifi cation and GIST tumorigenesis

Enhancer function :	We uncover that FOXF1 defi nes the core-regulatory circuitry in GIST through both direct transcriptional regulation and pioneer factor function.
Enhancer function experiment:	Immunohistochemical staining
Enhancer function experiment description:	We uncover that FOXF1 defi nes the core-regulatory circuitry in GIST through both direct transcriptional regulation and pioneer factor function.

SNP ID:

GeneName	Pathway Name	Source	Gene Number
FOXF1	FOXA2 and FOXA3 transcription factor networks	pid	45
ETV1	p38 signaling mediated by MAPKAP kinases	pid	21
KIT	AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )	inoh	173
KIT	AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )	inoh	173
KIT	C-MYB transcription factor network	pid	87
KIT	Constitutive Signaling by Aberrant PI3K in Cancer	reactome	61
KIT	Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )	inoh	236
KIT	EGFR1	netpath	475
KIT	KitReceptor	netpath	104
KIT	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	reactome	83
KIT	PIP3 activates AKT signaling	reactome	81
KIT	Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )	inoh	178
KIT	RAF/MAP kinase cascade	reactome	116
KIT	Regulation of KIT signaling	reactome	16
KIT	Signaling by SCF-KIT	reactome	37
KIT	Signaling events mediated by Stem cell factor receptor (c-Kit)	pid	53
KIT	VEGF signaling pathway ( VEGF signaling pathway )	inoh	183
KIT	Cytokine-cytokine receptor interaction	kegg	213
KIT	Endocytosis	kegg	201
KIT	Melanogenesis	kegg	100
KIT	Pathways in cancer	kegg	321
KIT	Acute myeloid leukemia	kegg	53
KIT	Hs_Kit_receptor_signaling_pathway_WP304_78799	wikipathways	46

The number on yellow line represents the distance between enhancer and target gene