About Enhancer
| Enhancer ID: | E_01_0030 |
| Species: | human |
| Position : | chr18:27930050-27932050   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Castration-resistant prostate cancer |
| Pubmed ID: | 29249800 |
| Enhancer experiment: | qRT-PCR,ChIP,3C |
| Enhancer experiment description: | DBC1 functions as a coactivator for AR-V7 and is required for the expression of AR-V7 target genes including CDH2, a mesenchymal marker linked to CRPC progression. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | DBC1 functions as a coactivator for AR-V7 and is required for the expression of AR-V7 target genes including CDH2, a mesenchymal marker linked to CRPC progression. |
About TF
| TF name : | CDH2 |
| TF experiment: | qRT-PCR,ChIP,3C |
| TF experiment description: | DBC1 functions as a coactivator for AR-V7 and is required for the expression of AR-V7 target genes including CDH2, a mesenchymal marker linked to CRPC progression. |
About Function
| Enhancer function : | DBC1 functions as a coactivator for AR-V7 and is required for the expression of AR-V7 target genes including CDH2, a mesenchymal marker linked to CRPC progression. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
DBC1 functions as a coactivator for AR-V7 and is required for the expression of AR-V7 target genes including CDH2, a mesenchymal marker linked to CRPC progression. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CDH2 | Adherens junctions interactions | reactome | 30 |
| CDH2 | Cadherin signaling pathway | panther | 147 |
| CDH2 | CDO in myogenesis | reactome | 29 |
| CDH2 | EGFR1 | netpath | 475 |
| CDH2 | FGF signaling pathway | pid | 55 |
| CDH2 | N-cadherin signaling events | pid | 36 |
| CDH2 | Posttranslational regulation of adherens junction stability and dissassembly | pid | 50 |
| CDH2 | Signaling events mediated by PTP1B | pid | 53 |
| CDH2 | Wnt | netpath | 118 |
| CDH2 | Wnt signaling pathway | panther | 250 |
| CDH2 | Cell adhesion molecules (CAMs) | kegg | 133 |
| CDH2 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 |
| CDH2 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
| CDH2 | Hs_Arrhythmogenic_Right_Ventricular_Cardiomyopathy_WP2118_71265 | wikipathways | 7 |
| CDH2 | Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 | wikipathways | 80 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene