About Enhancer
| Enhancer ID: | E_01_0029 |
| Species: | human |
| Position : | chr4:108045000-108047000   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Liver disease |
| Pubmed ID: | 29256825 |
| Enhancer experiment: | qRT-PCR,Immunofluorescence staining,PCR,Western blot |
| Enhancer experiment description: | ?-catenin nuclear translocation, T cell factor (TCF) and lymphoid enhancerbinding factor (LEF) up-regulation have been shown to be involved in canonical Wnt pathways [20], and in our studies, Western blot results showed that the amount of ?- catenin protein in nuclei was increased in treated cells |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | ?-catenin nuclear translocation, T cell factor (TCF) and lymphoid enhancerbinding factor (LEF) up-regulation have been shown to be involved in canonical Wnt pathways [20], and in our studies, Western blot results showed that the amount of ?- catenin protein in nuclei was increased in treated cells |
About TF
| TF name : | LEF1(LEF-1,TCF10,TCF1ALPHA,TCF7L3) |
| TF experiment: | qRT-PCR,Immunofluorescence staining,PCR,Western blot |
| TF experiment description: | ?-catenin nuclear translocation, T cell factor (TCF) and lymphoid enhancerbinding factor (LEF) up-regulation have been shown to be involved in canonical Wnt pathways [20], and in our studies, Western blot results showed that the amount of ?- catenin protein in nuclei was increased in treated cells |
About Function
| Enhancer function : | ?-catenin nuclear translocation, T cell factor (TCF) and lymphoid enhancerbinding factor (LEF) up-regulation have been shown to be involved in canonical Wnt pathways [20], and in our studies, Western blot results showed that the amount of ?- catenin protein in nuclei was increased in treated cells |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
?-catenin nuclear translocation, T cell factor (TCF) and lymphoid enhancerbinding factor (LEF) up-regulation have been shown to be involved in canonical Wnt pathways [20], and in our studies, Western blot results showed that the amount of ?- catenin protein in nuclei was increased in treated cells |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene