About Enhancer
| Enhancer ID: | E_01_0009 |
| Species: | human |
| Position : | chr8:144288666-144290666   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Gastric cancer |
| Pubmed ID: | 29339121 |
| Enhancer experiment: | ChIP,Real-time PCR,Western blot |
| Enhancer experiment description: | HSF1 was found to promote proliferation, migration and invasion of gastric cancer cells. |
About Target gene
| Target gene : | MORC2 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | HSF1 was found to promote proliferation, migration and invasion of gastric cancer cells.;EZH2, as the core and contributing catalytic subunit of PRC2, which is composed of EED;In view of this, we speculated that HSF1 may regulate ArgBP2 as well as associate with MORC2 |
About TF
| TF name : | HSF1(HSTF1)EZH2(ENX-1,ENX1b,KMT6,KMT6A,WVS,WVS2,EZH2) |
| TF experiment: | ChIP,Real-time PCR,Western blot |
| TF experiment description: | HSF1 was found to promote proliferation, migration and invasion of gastric cancer cells.;EZH2, as the core and contributing catalytic subunit of PRC2, which is composed of EED;In view of this, we speculated that HSF1 may regulate ArgBP2 as well as associate with MORC2 |
About Function
| Enhancer function : | HSF1 was found to promote proliferation, migration and invasion of gastric cancer cells. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
HSF1 was found to promote proliferation, migration and invasion of gastric cancer cells. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HSF1 | Attenuation phase | reactome | 28 |
| HSF1 | HSF1-dependent transactivation | reactome | 34 |
| HSF1 | HSF1 activation | reactome | 31 |
| HSF1 | p73 transcription factor network | pid | 80 |
| HSF1 | Regulation of HSF1-mediated heat shock response | reactome | 82 |
| HSF1 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
| EZH2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| EZH2 | Oxidative Stress Induced Senescence | reactome | 120 |
| EZH2 | PKMTs methylate histone lysines | reactome | 64 |
| EZH2 | PRC2 methylates histones and DNA | reactome | 71 |
| EZH2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| EZH2 | Hs_Interactome_of_polycomb_repressive_complex_2_(PRC2)_WP2916_88672 | wikipathways | 15 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene