About Enhancer
| Enhancer ID: | E_01_0007 |
| Species: | human |
| Position : | chr5:173229371-173231371   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Scleroderma associated pulmonary hypertensio |
| Pubmed ID: | 29342503 |
| Enhancer experiment: | Western blot,qPCR |
| Enhancer experiment description: | NKX2-5 is a homeobox transcription factor required for the formation of the heart and vessels during development, with significant postnatal downregulation and reactivation in disease states characterised by vascular remodelling. |
About Target gene
| Target gene : | -- |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | NKX2-5 is a homeobox transcription factor required for the formation of the heart and vessels during development, with significant postnatal downregulation and reactivation in disease states characterised by vascular remodelling.;TEAD1 is a member of TEA/ATTS domain family transcription regulators with distinct and important roles in VSMC differentiation and in cardiovascular disease |
About TF
| TF name : | NKX2-5(Csx,Nkx-2.5,Nkx2.5,tinman)TEAD1 |
| TF experiment: | Western blot,qPCR |
| TF experiment description: | NKX2-5 is a homeobox transcription factor required for the formation of the heart and vessels during development, with significant postnatal downregulation and reactivation in disease states characterised by vascular remodelling.;TEAD1 is a member of TEA/ATTS domain family transcription regulators with distinct and important roles in VSMC differentiation and in cardiovascular disease |
About Function
| Enhancer function : | NKX2-5 is a homeobox transcription factor required for the formation of the heart and vessels during development, with significant postnatal downregulation and reactivation in disease states characterised by vascular remodelling. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
NKX2-5 is a homeobox transcription factor required for the formation of the heart and vessels during development, with significant postnatal downregulation and reactivation in disease states characterised by vascular remodelling. |
About SNP
| SNP ID: | rs3095870 |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NKX2-5 | Physiological factors | reactome | 12 |
| NKX2-5 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| NKX2-5 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| NKX2-5 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| TEAD1 | PPARA activates gene expression | reactome | 113 |
| TEAD1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
| TEAD1 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene