About Enhancer
| Enhancer ID: | E_01975 |
| Species: | Homo sapiens |
| Position : | chr5:88396400-88396670   |
| Year: | 2025 |
| Title: | Massively parallel reporter assays and mouse transgenic assays provide correlated and complementary information about neuronal enhancer activity. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 40404660 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | iPSC-derived excitatory neurons |
| Cell Type: | excitatory neuron |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq; ATAC-seq; RNA-seq; MPRA |
| Low Throughput Method: | Transgenic Reporter Assay; RT-RT-qPCR; Reporter assay; Transgenic mouse enhancer assay |
About Target Gene
| Target gene : | MEF2C |
About TF
| TF name : | ASCL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ASCL1 | Notch-mediated HES/HEY network | pid | 48 |
| ASCL1 | Notch | netpath | 76 |
| ASCL1 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| ASCL1 | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer