About Enhancer
| Enhancer ID: | E_01961 |
| Species: | Homo sapiens |
| Position : | chr5:149631000-149636000   |
| Year: | 2022 |
| Title: | TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 34718356 |
| MONDO: | MONDO:0004989 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | Human breast cancer cell |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; RNA-seq; DNase-seq |
| Low Throughput Method: | Luciferase Reporter Assay; ChIP-RT-qPCR; CRISPR knockout; RT-RT-qPCR; Western blot |
About Target Gene
| Target gene : | TCOF1 |
About TF
| TF name : | FOSL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOSL1 | AP-1 transcription factor network | pid | 71 |
| FOSL1 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| FOSL1 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| FOSL1 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| FOSL1 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 5 |
| FOSL1 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) | inoh | 5 |
| FOSL1 | JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 12 |
| FOSL1 | JNK cascade ( CD4 T cell receptor signaling ) | inoh | 10 |
| FOSL1 | TGF-beta signaling pathway | panther | 88 |
| FOSL1 | Validated targets of C-MYC transcriptional activation | pid | 80 |
| FOSL1 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| FOSL1 | Wnt signaling pathway | kegg | 135 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer