About Enhancer
| Enhancer ID: | E_01954 |
| Species: | Homo sapiens |
| Position : | chr10:52442551-52444237   |
| Year: | 2024 |
| Title: | DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 39107271 |
| MONDO: | MONDO:0005184 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | AsPC-1 |
| CVCL ID: | CVCL_0152 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay; In vivo functional validation |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq, DNase-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPRi, CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR, Western blot, DNA pull-down assay; In vivo phenotyping |
About Target Gene
| Target gene : | DKK1 |
About TF
| TF name : | JUND |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| JUND | AP-1 transcription factor network | pid | 71 |
| JUND | ATF-2 transcription factor network | pid | 59 |
| JUND | EGFR1 | netpath | 475 |
| JUND | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| JUND | PDGFR-beta signaling pathway | pid | 125 |
| JUND | TGF-beta signaling pathway | panther | 88 |
| JUND | TGF_beta_Receptor | netpath | 220 |
| JUND | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| JUND | MAPK signaling pathway | kegg | 264 |
| JUND | Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 | wikipathways | 51 |
| JUND | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| JUND | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
| JUND | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01951 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
| E_01952 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
| E_01953 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
| E_01955 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
| E_01956 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
Expression of Target Genes for the Enhancer