About Enhancer
| Enhancer ID: | E_01953 |
| Species: | Homo sapiens |
| Position : | chr10:52442551-52444237   |
| Year: | 2024 |
| Title: | DKK1-SE recruits AP1 to activate the target gene DKK1 thereby promoting pancreatic cancer progression. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 39107271 |
| MONDO: | MONDO:0005184 |
| Tissue: | pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | PANC-1 |
| CVCL ID: | CVCL_0480 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay; In vivo functional validation |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq, DNase-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPRi, CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR, Western blot, DNA pull-down assay; In vivo phenotyping |
About Target Gene
| Target gene : | DKK1 |
About TF
| TF name : | FOSL2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOSL2 | AP-1 transcription factor network | pid | 71 |
| FOSL2 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 5 |
| FOSL2 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) | inoh | 5 |
| FOSL2 | JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 12 |
| FOSL2 | JNK cascade ( CD4 T cell receptor signaling ) | inoh | 10 |
| FOSL2 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| FOSL2 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01951 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
| E_01952 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
| E_01954 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
| E_01955 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
| E_01956 | chr10:52442551-52444237 | pancreas | malignant cell | pancreatic ductal adenocarcinoma |
Expression of Target Genes for the Enhancer