About Enhancer
| Enhancer ID: | E_01855 |
| Species: | Homo sapiens |
| Position : | chr8:128230503-128232194   |
| Year: | 2014 |
| Title: | Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal carcinoma |
| PMID: | 24662484 |
| MONDO: | MONDO:0024331 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HT-29 |
| CVCL ID: | CVCL_0320 |
| Cell Type: | epithelial cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Chromatin interaction assay; lncRNA-mediated enhancer regulation assay; Functional perturbation assay |
| High Throughput Method: | 3C-seq |
| Low Throughput Method: | CCAT1-L antisense oligonucleotide knockdown; 3C-qPCR; RNA-FISH; DNA-FISH; Northern blot; 3-prime RACE; CTCF-RNA interaction assay; TALEN-mediated in-cis overexpression; qRT-PCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
11 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03270 | chr8:128000000-128300000 | colon | malignant cell | colorectal cancer |
| E_01136 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01137 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01138 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01139 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01140 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01141 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_02985 | chr8:128206162-128314310 | colon | NA | NA |
| E_02910 | chr8:128220000-128250000 | heart | cardiac muscle cell | NA |
| E_02916 | chr8:128220000-128250000 | blood | lymphoblastoid cell | NA |
| E_03391 | chr8:128230172-128243000 | colon | NA | colorectal cancer |
Expression of Target Genes for the Enhancer