About Enhancer
| Enhancer ID: | E_01851 |
| Species: | Homo sapiens |
| Position : | chr8:128526339-128526710   |
| Year: | 2022 |
| Title: | The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 35676472 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Kidney proximal tubule epithelial cell |
| Cell Type: | kidney proximal tubule epithelial cell |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; ATAC-seq; RNA-seq |
| Low Throughput Method: | CRISPRi; ChIP-RT-qPCR; RT-RT-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | HNF1B |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HNF1B | Regulation of gene expression in early pancreatic precursor cells | reactome | 8 |
| HNF1B | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | reactome | 7 |
| HNF1B | Maturity onset diabetes of the young | kegg | 25 |
| HNF1B | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
17 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02842 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02843 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02844 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02845 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02846 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02847 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02848 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02849 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02850 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02851 | chr8:128520000-128551676 | stomach | malignant cell | esophageal adenocarcinoma |
| E_02852 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02853 | chr8:128520000-128551676 | prostate gland | malignant cell | prostate cancer |
| E_02887 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02888 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02889 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_02890 | chr8:128520000-128551676 | prostate gland | NA | NA |
| E_01817 | chr8:128526339-128526710 | kidney | malignant cell | renal cell carcinoma |
Expression of Target Genes for the Enhancer