About Enhancer
| Enhancer ID: | E_01840 |
| Species: | Homo sapiens |
| Position : | chr8:11446898-11447336   |
| Year: | 2022 |
| Title: | A risk variant for Barrett's esophagus and esophageal adenocarcinoma at chr8p23.1 affects enhancer activity and implicates multiple gene targets. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | esophageal adenocarcinoma |
| PMID: | 35766871 |
| MONDO: | MONDO:0005028 |
| Tissue: | esophagus |
| Tissue Ontology ID: | UBERON:0001043 |
| Cell Source: | OE33 |
| CVCL ID: | CVCL_0471 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; Disease-variant functional analysis |
| High Throughput Method: | eQTL analysis; GWAS |
| Low Throughput Method: | Luciferase Reporter Assay; CRISPR-Cas9 enhancer deletion; PCR validation; RT-qPCR; Allele-specific reporter assay; Reporter assay |
About Target Gene
| Target gene : | NEIL2 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
12 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01792 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01793 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01794 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01795 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01796 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01797 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01798 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01799 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01800 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01837 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01838 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
| E_01839 | chr8:11446898-11447336 | esophagus | malignant cell | esophageal adenocarcinoma |
Expression of Target Genes for the Enhancer