About Enhancer
| Enhancer ID: | E_01819 |
| Species: | Homo sapiens |
| Position : | chr11:69419632-69420080   |
| Year: | 2022 |
| Title: | The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | renal cell carcinoma |
| PMID: | 35676472 |
| MONDO: | MONDO:0005086 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | 786-M1A |
| CVCL ID: | CVCL_VR30 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay; Disease-variant functional analysis |
| High Throughput Method: | Pooled in vivo CRISPRi screen; ATAC-seq; ChIP-seq |
| Low Throughput Method: | CRISPRi; RT-qPCR; ChIP-qPCR |
About Target Gene
| Target gene : | MYEOV |
About TF
| TF name : | PAX8 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PAX8 | ID | netpath | 38 |
| PAX8 | Pathways in cancer | kegg | 321 |
| PAX8 | Thyroid cancer | kegg | 25 |
| PAX8 | Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
Expression of Target Genes for the Enhancer