About Enhancer
| Enhancer ID: | E_01816 |
| Species: | Homo sapiens |
| Position : | chr8:128132902-128133724   |
| Year: | 2022 |
| Title: | The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | renal cell carcinoma |
| PMID: | 35676472 |
| MONDO: | MONDO:0005086 |
| Tissue: | kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | Human renal cell carcinoma cell |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay; Disease-variant functional analysis |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPRi, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | HNF1B |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HNF1B | Regulation of gene expression in early pancreatic precursor cells | reactome | 8 |
| HNF1B | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | reactome | 7 |
| HNF1B | Maturity onset diabetes of the young | kegg | 25 |
| HNF1B | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03270 | chr8:128000000-128300000 | colon | malignant cell | colorectal cancer |
| E_01136 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01137 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01138 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01139 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01140 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01141 | chr8:128130000-128300000 | lymphoid tissue | B cell | mantle cell lymphoma |
| E_01850 | chr8:128132902-128133724 | kidney | kidney proximal tubule epithelial cell | NA |
Expression of Target Genes for the Enhancer