About Enhancer
| Enhancer ID: | E_01815 |
| Species: | Homo sapiens |
| Position : | chr11:69419632-69420080   |
| Year: | 2022 |
| Title: | The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | osteosarcoma |
| PMID: | 35676472 |
| MONDO: | MONDO:0009807 |
| Tissue: | bone element |
| Tissue Ontology ID: | UBERON:0001474 |
| Cell Source: | OS-LM1 |
| Cell Type: | osteosarcoma cell |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; ATAC-seq; RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay; CRISPRi; ChIP-RT-qPCR; RT-RT-qPCR; EMSA |
About Target Gene
| Target gene : | CCND1 |
About TF
| TF name : | PAX8 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PAX8 | ID | netpath | 38 |
| PAX8 | Pathways in cancer | kegg | 321 |
| PAX8 | Thyroid cancer | kegg | 25 |
| PAX8 | Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
Expression of Target Genes for the Enhancer