About Enhancer
| Enhancer ID: | E_01807 |
| Species: | Homo sapiens |
| Position : | chr8:128320000-128322000   |
| Year: | 2014 |
| Title: | Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 24662484 |
| MONDO: | MONDO:0005575 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT 116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, 3C-seq, RNA-seq |
| Low Throughput Method: | 3C, Luciferase Reporter Assay, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | MED1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MED1 | Activation of gene expression by SREBF (SREBP) | reactome | 42 |
| MED1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| MED1 | Circadian Clock | reactome | 49 |
| MED1 | Coregulation of Androgen receptor activity | pid | 61 |
| MED1 | Generic Transcription Pathway | reactome | 358 |
| MED1 | Hedgehog | netpath | 39 |
| MED1 | Nuclear Receptor transcription pathway | reactome | 51 |
| MED1 | PPARA activates gene expression | reactome | 113 |
| MED1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | reactome | 20 |
| MED1 | RORA activates gene expression | reactome | 27 |
| MED1 | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| MED1 | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
| MED1 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| MED1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| MED1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | reactome | 29 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer