About Enhancer
| Enhancer ID: | E_01773 |
| Species: | Homo sapiens |
| Position : | chr1:185660000-185710000   |
| Year: | 2024 |
| Title: | Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | nasopharyngeal carcinoma |
| PMID: | 38490101 |
| MONDO: | MONDO:0015459 |
| Tissue: | plantar part of pes |
| Tissue Ontology ID: | UBERON:0008338 |
| Cell Source: | C666-1 |
| CVCL ID: | CVCL_7949 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay; TF binding assay; Chromatin interaction assay; Chromatin-state profiling |
| High Throughput Method: | Hi-C, 4C-seq, ChIP-seq, RNA-seq; RNA-seq; ChIP-seq; Hi-C; ChIA-PET; 4C-seq |
| Low Throughput Method: | siRNA Knockdown, RT-RT-qPCR, Western blot; ChIP; 4C |
About Target Gene
| Target gene : | PTGS2 |
About TF
| TF name : | REL |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| REL | Activation of NF-kappaB in B cells | reactome | 66 |
| REL | Apoptosis signaling pathway | panther | 104 |
| REL | Atypical NF-kappaB pathway | pid | 14 |
| REL | BCR | netpath | 161 |
| REL | IL1 | netpath | 69 |
| REL | Leptin | netpath | 98 |
| REL | RANKL | netpath | 84 |
| REL | Regulation of Androgen receptor activity | pid | 54 |
| REL | TCR | netpath | 261 |
| REL | TNFalpha | netpath | 274 |
| REL | Hs_TNF_alpha_Signaling_Pathway_WP231_89895 | wikipathways | 61 |
| REL | Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 | wikipathways | 60 |
| REL | Hs_IL-1_signaling_pathway_WP195_89932 | wikipathways | 34 |
| REL | Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 | wikipathways | 71 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01774 | chr1:185660000-185710000 | plantar part of pes | malignant cell | nasopharyngeal carcinoma |
Expression of Target Genes for the Enhancer