About Enhancer
| Enhancer ID: | E_01766 |
| Species: | Homo sapiens |
| Position : | chr14:77635927-77639784   |
| Year: | 2017 |
| Title: | Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Alzheimer's Disease |
| PMID: | 27651453 |
| Cell Source: | SH-SY5Y |
| CVCL ID: | CVCL_0019 |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; Disease-associated enhancer analysis |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; 3C; RNAi/siRNA/shRNA |
About Target Gene
| Target gene : | NGB |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer