About Enhancer
| Enhancer ID: | E_01745 |
| Species: | Homo sapiens |
| Position : | chr6:31132200-31132800   |
| Year: | 2018 |
| Title: | The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 30590035 |
| Tissue: | gonad |
| Tissue Ontology ID: | UBERON:0000991 |
| Cell Source: | human primordial germ cells (hPGCs) |
| Cell Type: | primordial germ cell |
| Cell Ontology ID: | CL:0000670 |
| Experiment Type: | Enhancer activity; TF binding; endogenous enhancer deletion; germline differentiation assay; Endogenous enhancer perturbation; Chromatin-state profiling |
| High Throughput Method: | ATAC-seq; TFAP2C ChIP-seq integration; RNA-seq |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; TFAP2C ChIP-qPCR; qRT-PCR; flow cytometry; immunofluorescence/hPGCLC differentiation; CRISPR-Cas9 endogenous deletion/editing |
About Target Gene
| Target gene : | POU5F1 |
About TF
| TF name : | TFAP2C |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TFAP2C | Validated transcriptional targets of TAp63 isoforms | pid | 54 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer