About Enhancer
| Enhancer ID: | E_01720 |
| Species: | Homo sapiens |
| Position : | chr12:47732000-47733500   |
| Year: | 2017 |
| Title: | Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | cutaneous melanoma |
| PMID: | 29149598 |
| MONDO: | MONDO:0005012 |
| Tissue: | zone of skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | SK-MEL-147 |
| CVCL ID: | CVCL_3876 |
| Cell Type: | melanoma cell |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq; ATAC-seq; RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay; CRISPR Knockout; RT-RT-qPCR |
About Target Gene
| Target gene : | AMIGO2 |
About TF
| TF name : | FOSL2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOSL2 | AP-1 transcription factor network | pid | 71 |
| FOSL2 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 5 |
| FOSL2 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) | inoh | 5 |
| FOSL2 | JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 12 |
| FOSL2 | JNK cascade ( CD4 T cell receptor signaling ) | inoh | 10 |
| FOSL2 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| FOSL2 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer