About Enhancer
| Enhancer ID: | E_01702 |
| Species: | Homo sapiens |
| Position : | chr9:133401000-133404500   |
| Year: | 2016 |
| Title: | BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | ovarian carcinoma |
| PMID: | 27803105 |
| MONDO: | MONDO:0005140 |
| Tissue: | breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | ZR-75-1 |
| CVCL ID: | CVCL_0588 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay, Chromatin interaction assay; In vivo functional validation |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, RT-RT-qPCR; In vivo phenotyping |
About Target Gene
| Target gene : | ALDH1A1 |
About TF
| TF name : | BRD4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer