About Enhancer
| Enhancer ID: | E_01701 |
| Species: | Homo sapiens |
| Position : | chr11:69916000-70050000   |
| Year: | 2019 |
| Title: | Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | SDH-deficient gastrointestinal stromal tumor |
| PMID: | 31666694 |
| MONDO: | MONDO:0011719 |
| Tissue: | small intestine |
| Tissue Ontology ID: | UBERON:0002108 |
| Cell Source: | Primary GIST tumor samples |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; Chromatin interaction assay |
| High Throughput Method: | H3K27ac ChIP-seq; CTCF ChIP-seq; RNA-seq; Hi-C; CTCF HiChIP; 4C-seq; Bisulfite sequencing |
| Low Throughput Method: | CRISPR/Cas9 CTCF motif deletion; qRT-PCR; ChIP-qPCR; Patient-derived xenograft drug response |
About Target Gene
| Target gene : | FGF4 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer