About Enhancer
| Enhancer ID: | E_01693 |
| Species: | Homo sapiens |
| Position : | chr2:188184262-188184791   |
| Year: | 2024 |
| Title: | Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | coronary artery disorder |
| PMID: | 38602103 |
| MONDO: | MONDO:0005010 |
| Tissue: | blood vessel |
| Tissue Ontology ID: | UBERON:0001981 |
| Cell Source: | Human aortic endothelial cells (HAECs) |
| Cell Type: | endothelial cell |
| Cell Ontology ID: | CL:0000115 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| High Throughput Method: | ATAC-seq; RNA-seq; ChIP-seq; STARR-seq |
| Low Throughput Method: | Luciferase reporter assay; CRISPR-Cas9 enhancer deletion; ChIP-qPCR; EMSA; RT-qPCR; Reporter assay; siRNA knockdown |
About Target Gene
| Target gene : | CALCRL |
About TF
| TF name : | HSF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HSF1 | Attenuation phase | reactome | 28 |
| HSF1 | HSF1-dependent transactivation | reactome | 34 |
| HSF1 | HSF1 activation | reactome | 31 |
| HSF1 | p73 transcription factor network | pid | 80 |
| HSF1 | Regulation of HSF1-mediated heat shock response | reactome | 82 |
| HSF1 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer