About Enhancer
| Enhancer ID: | E_01690 |
| Species: | Homo sapiens |
| Position : | chrX:153492724-153500546   |
| Year: | 2026 |
| Title: | Enhancer-mediated NR2F2 recruitment activates BGN to promote tumor growth and shape tumor microenvironment in papillary thyroid cancer. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | thyroid gland carcinoma |
| PMID: | 41328346 |
| MONDO: | MONDO:0015075 |
| Tissue: | thyroid gland |
| Tissue Ontology ID: | UBERON:0002046 |
| Cell Source: | Thyroid carcinoma cell |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay; Enhancer activity assay; Endogenous enhancer perturbation |
| High Throughput Method: | ChIP-seq, RNA-seq; single-cell RNA-seq; RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, CRISPRi, 3C assay, RT-RT-qPCR, Western blot; CRISPRi; Luciferase reporter assay; Flow cytometry |
About Target Gene
| Target gene : | BGN |
About TF
| TF name : | NR2F2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NR2F2 | FOXA1 transcription factor network | pid | 45 |
| NR2F2 | Regulation of Telomerase | pid | 70 |
| NR2F2 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| NR2F2 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer