About Enhancer
| Enhancer ID: | E_01670 |
| Species: | Homo sapiens |
| Position : | chr12:121799763-121803094   |
| Year: | 2023 |
| Title: | Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis. |
| Genome Build: | hg38 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 37756562 |
| MONDO: | MONDO:0007256 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | SNU-387 |
| CVCL ID: | CVCL_0250 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | SE functional perturbation; EMT / metastasis validation; In vivo functional validation |
| High Throughput Method: | H3K27ac ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPRi; RT-qPCR; LINC01089 knockdown; migration/invasion assay; in vivo metastasis assay; In vivo phenotyping |
About Target Gene
| Target gene : | LINC01089 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
6 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01616 | chr12:121799763-121803094 | liver | hepatocyte | hepatocellular carcinoma |
| E_01617 | chr12:121799763-121803094 | liver | malignant cell | hepatocellular carcinoma |
| E_01637 | chr12:121799763-121803094 | liver | malignant cell | hepatocellular carcinoma |
| E_01638 | chr12:121799763-121803094 | liver | malignant cell | hepatocellular carcinoma |
| E_01666 | chr12:121799763-121803094 | liver | hepatocyte | hepatocellular carcinoma |
| E_01669 | chr12:121799763-121803094 | liver | malignant cell | hepatocellular carcinoma |
Expression of Target Genes for the Enhancer