About Enhancer
| Enhancer ID: | E_01650 |
| Species: | Homo sapiens |
| Position : | chr11:2201926-2215265   |
| Year: | 2022 |
| Title: | Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal adenocarcinoma |
| PMID: | 34059508 |
| MONDO: | MONDO:0005008 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | SW480 |
| CVCL ID: | CVCL_0546 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer functional validation; Functional perturbation assay; Chromatin interaction assay |
| High Throughput Method: | H3K27ac ChIP-seq; H3K27ac HiChIP; RNA-seq |
| Low Throughput Method: | CRISPRi (dCas9-KRAB); ChIP-qPCR; 3C; ASCL2 mRNA quantification; cell proliferation assay |
About Target Gene
| Target gene : | ASCL2 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer