About Enhancer
| Enhancer ID: | E_01649 |
| Species: | Homo sapiens |
| Position : | chr11:2223156-2236495   |
| Year: | 2022 |
| Title: | Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal adenocarcinoma |
| PMID: | 34059508 |
| MONDO: | MONDO:0005008 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | SW480 |
| CVCL ID: | CVCL_0546 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer functional validation; Functional perturbation assay; Chromatin interaction assay |
| High Throughput Method: | H3K27ac ChIP-seq; H3K27ac HiChIP; RNA-seq |
| Low Throughput Method: | CRISPRi (dCas9-KRAB); ChIP-qPCR; 3C; ASCL2 mRNA quantification; cell proliferation assay |
About Target Gene
| Target gene : | ASCL2 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03318 | chr11:2219531-2239062 | lung | malignant cell | Lung Cancer |
| E_03294 | chr11:2227598-2233058 | colon | malignant cell | colorectal cancer |
| E_01618 | chr11:2233643-2234213 | colon | epithelial cell | colorectal adenocarcinoma |
| E_01645 | chr11:2233643-2234213 | colon | malignant cell | colorectal adenocarcinoma |
| E_01646 | chr11:2233643-2234213 | colon | malignant cell | colorectal adenocarcinoma |
| E_03295 | chr11:2234046-2237062 | colon | malignant cell | colorectal cancer |
| E_03296 | chr11:2236031-2239626 | colon | malignant cell | colorectal cancer |
Expression of Target Genes for the Enhancer