About Enhancer
| Enhancer ID: | E_01635 |
| Species: | Homo sapiens |
| Position : | chr19:12995236-12998015   |
| Year: | 2023 |
| Title: | Identification of a genomic DNA sequence that quantitatively modulates KLF1 transcription factor expression in differentiating human hematopoietic cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 37165057 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | KU812/JK1 assay models |
| Cell Type: | erythroid progenitor cell |
| Cell Ontology ID: | CL:0000038 |
| Experiment Type: | Enhancer chromatin-accessibility assay; TF binding assay; Endogenous enhancer editing assay; In vivo functional validation |
| High Throughput Method: | ATAC-seq; GATA1/SMAD1/TAL1/ETV6 ChIP-seq integration; edited-locus deep sequencing |
| Low Throughput Method: | TALEN/Cpf1 editing; luciferase reporter; ChIP-qPCR; qRT-PCR; erythroid differentiation analysis; In vivo phenotyping |
About Target Gene
| Target gene : | KLF1 |
About TF
| TF name : | ETV6 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ETV6 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| ETV6 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| ETV6 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| ETV6 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| ETV6 | MAPK signaling pathway - fly | kegg | 16 |
| ETV6 | Dorso-ventral axis formation | kegg | 25 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer