About Enhancer
| Enhancer ID: | E_01626 |
| Species: | Homo sapiens |
| Position : | chr9:94190762-94191795   |
| Year: | 2022 |
| Title: | Lineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | obesity |
| PMID: | 36224171 |
| MONDO: | MONDO:0011122 |
| Tissue: | mesenchyme of umbilical cord |
| Tissue Ontology ID: | UBERON:0003422 |
| Cell Source: | Primary human umbilical cord-derived hMSCs after adipogenic differentiation |
| Cell Type: | adipocyte |
| Cell Ontology ID: | CL:0000136 |
| Experiment Type: | Super-enhancer constituent activity assay; Functional enhancer perturbation assay; Lineage-specific differentiation assay; Disease-variant functional analysis |
| High Throughput Method: | H3K27ac ChIP-seq; DNase-seq; RNA-seq; GWAS |
| Low Throughput Method: | CRISPR-Cas9 deletion of NFIL3-SE functional region FR3; RT-qPCR; Nile red staining |
About Target Gene
| Target gene : | NFIL3 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer