About Enhancer
| Enhancer ID: | E_01611 |
| Species: | Homo sapiens |
| Position : | chr19:12995236-12998015   |
| Year: | 2023 |
| Title: | Identification of a genomic DNA sequence that quantitatively modulates KLF1 transcription factor expression in differentiating human hematopoietic cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 37165057 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | primary human CD34+-derived erythroid cells |
| Cell Type: | erythroid progenitor cell |
| Cell Ontology ID: | CL:0000038 |
| Experiment Type: | Enhancer chromatin-accessibility assay; TF binding assay; Endogenous enhancer editing assay; In vivo functional validation |
| High Throughput Method: | ATAC-seq; GATA1/SMAD1/TAL1/ETV6 ChIP-seq integration; edited-locus deep sequencing |
| Low Throughput Method: | TALEN/Cpf1 editing; luciferase reporter; ChIP-qPCR; qRT-PCR; erythroid differentiation analysis; In vivo phenotyping |
About Target Gene
| Target gene : | KLF1 |
About TF
| TF name : | GATA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA1 | C-MYB transcription factor network | pid | 87 |
| GATA1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA1 | IL3 | netpath | 84 |
| GATA1 | Notch-mediated HES/HEY network | pid | 48 |
| GATA1 | p73 transcription factor network | pid | 80 |
| GATA1 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer