About Enhancer
| Enhancer ID: | E_01608 |
| Species: | Homo sapiens |
| Position : | chr7:131323622-131334609   |
| Year: | 2024 |
| Title: | CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | triple-negative breast carcinoma |
| PMID: | 39186674 |
| MONDO: | MONDO:0005494 |
| Tissue: | mammary gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | MDA-MB-436 |
| CVCL ID: | CVCL_0623 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | CRISPR-Cas9 knockout loss-of-function, dCas9-KRAB CRISPRi repression, Hi-C chromatin looping validation, CasRx eRNA knockdown |
| High Throughput Method: | ChIP-seq(H3K27ac); GRO-seq; ATAC-seq; RNA-seq; Hi-C, scATAC-seq, scRNA-seq; TCGA bulk omics; single-cell RNA-seq; Hi-C |
| Low Throughput Method: | qRT-PCR, transwell migration assay, crystal violet proliferation assay, mouse mammary fat pad xenograft, tail vein metastasis model; IHC staining |
About Target Gene
| Target gene : | PODXL |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer