About Enhancer
| Enhancer ID: | E_01596 |
| Species: | Homo sapiens |
| Position : | chr11:1986889-1991809   |
| Year: | 2025 |
| Title: | Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | hepatocellular carcinoma |
| PMID: | 39799319 |
| MONDO: | MONDO:0007256 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | HCCLM3 |
| CVCL ID: | CVCL_6832 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; epigenetic activation assay; chromatin interaction assay; functional perturbation assay; disease phenotype assay; In vivo functional validation |
| High Throughput Method: | TCGA transcriptomic correlation analysis |
| Low Throughput Method: | Wild-type/mutant dual-luciferase reporter assay; miR-483-5p mimic/inhibitor perturbation; ChIP-qPCR; IGF2/H19 eRNA qRT-PCR; 3C-PCR; RIP-qPCR; co-immunoprecipitation; MED1 rescue; qRT-PCR; Western blot; CCK-8 assay; Transwell assay; In vivo phenotyping |
About Target Gene
| Target gene : | H19 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
3 found
Expression of Target Genes for the Enhancer