About Enhancer
| Enhancer ID: | E_01594 |
| Species: | Homo sapiens |
| Position : | chr10:6094588-6094934   |
| Year: | 2017 |
| Title: | Discovery of stimulation-responsive immune enhancers with CRISPR activation. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | autoimmune disease |
| PMID: | 28854172 |
| MONDO: | MONDO:0007179 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | primary human CD4-positive T cells |
| Cell Type: | CD4-positive, alpha-beta T cell |
| Cell Ontology ID: | CL:0000624 |
| Experiment Type: | Disease-variant functional validation; endogenous response-eQTL assay; Endogenous enhancer perturbation; Disease-variant functional analysis; In vivo functional validation |
| High Throughput Method: | RNA-seq; H3K27ac HiChIP; ATAC-seq; GWAS fine-mapping; response-eQTL analysis |
| Low Throughput Method: | Anti-CD3/CD28 stimulation; rs61839660 genotype-expression analysis; flow cytometry; CRISPRa; Mouse genetic deletion/knock-in |
About Target Gene
| Target gene : | IL2RA |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01593 | chr10:6094588-6094934 | blood | T cell | autoimmune disease |
Expression of Target Genes for the Enhancer