About Enhancer
| Enhancer ID: | E_01584 |
| Species: | Homo sapiens |
| Position : | chr12:48395262-48395977   |
| Year: | 2014 |
| Title: | Up-regulation of type II collagen gene by 17汕-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor 汐. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25081415 |
| Tissue: | articular cartilage |
| Cell Source: | Primary articular chondrocytes |
| Cell Type: | chondrocyte |
| Cell Ontology ID: | CL:0000138 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Functional perturbation assay |
| Low Throughput Method: | Luciferase Reporter Assay; ChIP; Re-ChIP; EMSA; siRNA knockdown; RT-qPCR |
About Target Gene
| Target gene : | COL2A1 |
About TF
| TF name : | SP3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SP3 | Leptin | netpath | 98 |
| SP3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| SP3 | Regulation of Telomerase | pid | 70 |
| SP3 | SUMOylation of transcription factors | reactome | 14 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer