About Enhancer
| Enhancer ID: | E_01569 |
| Species: | Homo sapiens |
| Position : | chr12:48368875-48369590   |
| Year: | 2014 |
| Title: | Up-regulation of type II collagen gene by 17汕-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor 汐. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | osteoarthritis |
| PMID: | 25081415 |
| MONDO: | MONDO:0005178 |
| Tissue: | cartilage tissue |
| Tissue Ontology ID: | UBERON:0002418 |
| Cell Source: | dedifferentiated OA-phenotype human articular chondrocytes |
| Cell Type: | chondrocyte |
| Cell Ontology ID: | CL:0000138 |
| Experiment Type: | Hormone-responsive enhancer/TF-complex activity assay; TF binding assay; In vivo functional validation |
| Low Throughput Method: | 17汕-estradiol stimulation; ChIP/Re-ChIP; TF siRNA; DNA-binding assay; reporter assay; RT-qPCR; Western blot; ChIP; siRNA knockdown; In vivo phenotyping |
About Target Gene
| Target gene : | COL2A1 |
About TF
| TF name : | SP3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SP3 | Leptin | netpath | 98 |
| SP3 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| SP3 | Regulation of Telomerase | pid | 70 |
| SP3 | SUMOylation of transcription factors | reactome | 14 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
17 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01553 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | NA |
| E_01554 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | NA |
| E_01555 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | NA |
| E_01556 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | NA |
| E_01566 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | osteoarthritis |
| E_01567 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | osteoarthritis |
| E_01568 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | osteoarthritis |
| E_01585 | chr12:48368875-48369590 | breast | NA | osteoarthritis |
| E_01586 | chr12:48368875-48369590 | breast | NA | osteoarthritis |
| E_01587 | chr12:48368875-48369590 | breast | NA | osteoarthritis |
| E_01588 | chr12:48368875-48369590 | breast | NA | osteoarthritis |
| E_05292 | chr12:48368959-48369159 | NA | malignant cell | NA |
| E_05293 | chr12:48368959-48369159 | NA | malignant cell | NA |
| E_05298 | chr12:48368959-48369159 | NA | NA | NA |
| E_05299 | chr12:48368959-48369159 | NA | NA | NA |
| E_04571 | chr12:48369059-48369213 | NA | NA | NA |
| E_04574 | chr12:48369059-48369213 | cartilage tissue | chondrocyte | NA |
Expression of Target Genes for the Enhancer