About Enhancer
| Enhancer ID: | E_01553 |
| Species: | Homo sapiens |
| Position : | chr12:48368875-48369590   |
| Year: | 2014 |
| Title: | Up-regulation of type II collagen gene by 17汕-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor 汐. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 25081415 |
| Tissue: | cartilage tissue |
| Tissue Ontology ID: | UBERON:0002418 |
| Cell Source: | primary differentiated human articular chondrocytes |
| Cell Type: | chondrocyte |
| Cell Ontology ID: | CL:0000138 |
| Experiment Type: | Hormone-responsive enhancer/TF-complex activity assay; TF binding assay; In vivo functional validation |
| Low Throughput Method: | 17汕-estradiol stimulation; ChIP/Re-ChIP; TF siRNA; DNA-binding assay; reporter assay; RT-qPCR; Western blot; ChIP; siRNA knockdown; In vivo phenotyping |
About Target Gene
| Target gene : | COL2A1 |
About TF
| TF name : | ESR1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ESR1 | AndrogenReceptor | netpath | 167 |
| ESR1 | AP-1 transcription factor network | pid | 71 |
| ESR1 | ATF-2 transcription factor network | pid | 59 |
| ESR1 | Cellular roles of Anthrax toxin | pid | 25 |
| ESR1 | FOXA1 transcription factor network | pid | 45 |
| ESR1 | FOXM1 transcription factor network | pid | 43 |
| ESR1 | Leptin | netpath | 98 |
| ESR1 | LKB1 signaling events | pid | 43 |
| ESR1 | Nuclear Receptor transcription pathway | reactome | 51 |
| ESR1 | Nuclear signaling by ERBB4 | reactome | 25 |
| ESR1 | Plasma membrane estrogen receptor signaling | pid | 42 |
| ESR1 | Prolactin | netpath | 105 |
| ESR1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| ESR1 | Regulation of Telomerase | pid | 70 |
| ESR1 | Signaling events mediated by HDAC Class II | pid | 58 |
| ESR1 | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| ESR1 | Tamoxifen Action Pathway | smpdb | 10 |
| ESR1 | Tamoxifen Metabolism Pathway | smpdb | 10 |
| ESR1 | TGF_beta_Receptor | netpath | 220 |
| ESR1 | Validated nuclear estrogen receptor alpha network | pid | 65 |
| ESR1 | Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 | wikipathways | 36 |
| ESR1 | Hs_Leptin_signaling_pathway_WP2034_89856 | wikipathways | 37 |
| ESR1 | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| ESR1 | Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687 | wikipathways | 16 |
| ESR1 | Hs_Estrogen_signaling_pathway_WP712_78491 | wikipathways | 13 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
17 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01554 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | NA |
| E_01555 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | NA |
| E_01556 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | NA |
| E_01566 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | osteoarthritis |
| E_01567 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | osteoarthritis |
| E_01568 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | osteoarthritis |
| E_01569 | chr12:48368875-48369590 | cartilage tissue | chondrocyte | osteoarthritis |
| E_01585 | chr12:48368875-48369590 | breast | NA | osteoarthritis |
| E_01586 | chr12:48368875-48369590 | breast | NA | osteoarthritis |
| E_01587 | chr12:48368875-48369590 | breast | NA | osteoarthritis |
| E_01588 | chr12:48368875-48369590 | breast | NA | osteoarthritis |
| E_05292 | chr12:48368959-48369159 | NA | malignant cell | NA |
| E_05293 | chr12:48368959-48369159 | NA | malignant cell | NA |
| E_05298 | chr12:48368959-48369159 | NA | NA | NA |
| E_05299 | chr12:48368959-48369159 | NA | NA | NA |
| E_04571 | chr12:48369059-48369213 | NA | NA | NA |
| E_04574 | chr12:48369059-48369213 | cartilage tissue | chondrocyte | NA |
Expression of Target Genes for the Enhancer