About Enhancer
| Enhancer ID: | E_01536 |
| Species: | Homo sapiens |
| Position : | chr7:150360481-150366493   |
| Year: | 2017 |
| Title: | Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 28028313 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat and primary T-ALL models |
| Cell Type: | T-lymphoblast/T-ALL cell |
| Experiment Type: | Oncogenic TF occupancy; enhancer activity; endogenous enhancer deletion |
| High Throughput Method: | TAL1/RUNX1/GATA3/H3K27ac ChIP-seq; transcriptomic analysis |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; luciferase reporter; ChIP-qPCR; qRT-PCR; in-vivo reporter assays |
About Target Gene
| Target gene : | GIMAP5 |
About TF
| TF name : | TAL1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
2 found
Expression of Target Genes for the Enhancer