About Enhancer
| Enhancer ID: | E_01510 |
| Species: | Homo sapiens |
| Position : | chr7:117125000-117126200   |
| Year: | 2016 |
| Title: | Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26673704 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | Human normal colon epithelial cell |
| Cell Type: | colon epithelial cell |
| Cell Ontology ID: | CL:0011108 |
| Experiment Type: | Enhancer activity assay, TF binding assay; Endogenous enhancer perturbation |
| Low Throughput Method: | ChIP-RT-qPCR; CRISPR-Cas9 endogenous deletion/editing; siRNA knockdown |
About Target Gene
| Target gene : | CFTR |
About TF
| TF name : | FOXA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA1 | AndrogenReceptor | netpath | 167 |
| FOXA1 | Direct p53 effectors | pid | 141 |
| FOXA1 | FOXA1 transcription factor network | pid | 45 |
| FOXA1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer