About Enhancer
| Enhancer ID: | E_01497 |
| Species: | Homo sapiens |
| Position : | chr7:117228051-117229440   |
| Year: | 2016 |
| Title: | Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26673704 |
| Cell Source: | Caco-2 |
| CVCL ID: | CVCL_0025 |
| Experiment Type: | TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation |
| Low Throughput Method: | CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; 4C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | CFTR |
About TF
| TF name : | CDX2 |
About Regulatory State
| Regulatory State : | Repressed |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CDX2 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation | reactome | 10 |
| CDX2 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01471 | chr7:117227200-117229503 | intestinal epithelium | intestinal epithelial cell | NA |
| E_01472 | chr7:117227200-117229503 | intestinal epithelium | intestinal epithelial cell | NA |
| E_02405 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_02406 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_02407 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_02408 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_01498 | chr7:117228051-117229440 | NA | NA | NA |
| E_01499 | chr7:117228051-117229440 | NA | NA | NA |
| E_01500 | chr7:117228051-117229440 | NA | NA | NA |
Expression of Target Genes for the Enhancer