About Enhancer
| Enhancer ID: | E_01489 |
| Species: | Homo sapiens |
| Position : | chr6:32543534-32553534   |
| Year: | 2020 |
| Title: | A super enhancer controls expression and chromatin architecture within the MHC class II locus. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 31753848 |
| Tissue: | lymphoid tissue |
| Tissue Ontology ID: | UBERON:0001744 |
| Cell Source: | Raji |
| CVCL ID: | CVCL_0511 |
| Cell Type: | B lymphocyte |
| Experiment Type: | Functional perturbation assay; Chromatin interaction assay; Enhancer activity assay |
| High Throughput Method: | ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPR-Cas9 deletion; ChIP-qPCR; RT-qPCR; 3C; Flow cytometry; CRISPR-Cas9 |
About Target Gene
| Target gene : | HLA-DQA1 |
About TF
| TF name : | CIITA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CIITA | Interferon gamma signaling | reactome | 88 |
| CIITA | Antigen processing and presentation | kegg | 75 |
| CIITA | Toxoplasmosis | kegg | 131 |
| CIITA | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer