About Enhancer
| Enhancer ID: | E_01487 |
| Species: | Homo sapiens |
| Position : | chr1:47677544-47677944   |
| Year: | 2023 |
| Title: | TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 36632736 |
| MONDO: | MONDO:0004963 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | engineered Jurkat models |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Somatic neo-enhancer discovery and functional engineering |
| High Throughput Method: | WGS; H3K27ac ChIP-seq; H3K4me3 ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPR engineering; reporter assay; Sanger sequencing; allele-specific expression analysis |
About Target Gene
| Target gene : | TAL1 |
About TF
| TF name : | MYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYB | AP-1 transcription factor network | pid | 71 |
| MYB | C-MYB transcription factor network | pid | 87 |
| MYB | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| MYB | IL2 signaling events mediated by PI3K | pid | 38 |
| MYB | IL4-mediated signaling events | pid | 66 |
| MYB | Notch-mediated HES/HEY network | pid | 48 |
| MYB | Prolactin | netpath | 105 |
| MYB | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01480 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01481 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01482 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01483 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01505 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01506 | chr1:47677466-47678021 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_02024 | chr1:47677539-47677958 | blood | T cell | T-cell acute lymphoblastic leukemia |
| E_01468 | chr1:47677544-47677944 | blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer