About Enhancer
| Enhancer ID: | E_01478 |
| Species: | Homo sapiens |
| Position : | chr6:32595564-32596093   |
| Year: | 2020 |
| Title: | A super enhancer controls expression and chromatin architecture within the MHC class II locus. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Burkitt lymphoma |
| PMID: | 31753848 |
| MONDO: | MONDO:0007243 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Raji |
| CVCL ID: | CVCL_0511 |
| Cell Type: | B lymphocyte |
| Experiment Type: | TF binding assay; chromatin interaction assay |
| High Throughput Method: | CTCF ChIP-seq; H3K27ac ChIP-seq |
| Low Throughput Method: | ChIP-qPCR; 3C; CRISPR-Cas9 XL9-region deletion; CRISPR-Cas9 |
About Target Gene
| Target gene : | HLA-DQA1 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer