About Enhancer
| Enhancer ID: | E_01476 |
| Species: | Homo sapiens |
| Position : | chr21:38376000-38377000   |
| Year: | 2023 |
| Title: | EVI1 drives leukemogenesis through aberrant ERG activation. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 36095844 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | HNT-34 |
| CVCL ID: | CVCL_2071 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Functional validation, TF binding; In vivo functional validation |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPR KO, shRNA KD, RT-RT-qPCR, Western blot, Transgenic reporter assay; In vivo phenotyping |
About Target Gene
| Target gene : | ERG |
About TF
| TF name : | MECOM |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MECOM | PKMTs methylate histone lysines | reactome | 64 |
| MECOM | MAPK signaling pathway | kegg | 264 |
| MECOM | Pathways in cancer | kegg | 321 |
| MECOM | Chronic myeloid leukemia | kegg | 69 |
| MECOM | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer