About Enhancer
| Enhancer ID: | E_01472 |
| Species: | Homo sapiens |
| Position : | chr7:117227200-117229503   |
| Year: | 2016 |
| Title: | Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26673704 |
| Tissue: | intestinal epithelium |
| Tissue Ontology ID: | UBERON:0001277 |
| Cell Source: | human epithelial comparison models |
| Cell Type: | intestinal epithelial cell |
| Cell Ontology ID: | CL:0002563 |
| Experiment Type: | Endogenous enhancer deletion; chromatin interaction; TF occupancy |
| High Throughput Method: | 4C-seq; DNase/open-chromatin and ChIP-seq integration |
| Low Throughput Method: | CRISPR-Cas9 ~1.2-kb enhancer deletion; FOXA2 ChIP-qPCR; RT-qPCR; 3C/4C validation; CRISPR-Cas9; siRNA knockdown |
About Target Gene
| Target gene : | CFTR |
About TF
| TF name : | FOXA2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA2 | FOXA1 transcription factor network | pid | 45 |
| FOXA2 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA2 | Hedgehog signaling events mediated by Gli proteins | pid | 49 |
| FOXA2 | Regulation of gene expression in beta cells | reactome | 17 |
| FOXA2 | Maturity onset diabetes of the young | kegg | 25 |
| FOXA2 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
| FOXA2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
| FOXA2 | Hs_Heart_Development_WP1591_90186 | wikipathways | 28 |
| FOXA2 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01471 | chr7:117227200-117229503 | intestinal epithelium | intestinal epithelial cell | NA |
| E_02405 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_02406 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_02407 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_02408 | chr7:117228049-117229449 | intestine | intestinal epithelial cell | NA |
| E_01497 | chr7:117228051-117229440 | NA | NA | NA |
| E_01498 | chr7:117228051-117229440 | NA | NA | NA |
| E_01499 | chr7:117228051-117229440 | NA | NA | NA |
| E_01500 | chr7:117228051-117229440 | NA | NA | NA |
Expression of Target Genes for the Enhancer