About Enhancer
| Enhancer ID: | E_01455 |
| Species: | Homo sapiens |
| Position : | chr12:86257615-86258800   |
| Year: | 2020 |
| Title: | Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | uveal melanoma |
| PMID: | 33196849 |
| MONDO: | MONDO:0006486 |
| Tissue: | eye |
| Tissue Ontology ID: | UBERON:0000970 |
| Cell Source: | OCM-8 |
| CVCL ID: | CVCL_6938 |
| Cell Type: | uveal melanoma metastatic cell |
| Experiment Type: | Enhancer activity assay; Functional perturbation assay; Chromatin interaction assay |
| High Throughput Method: | RNA-seq; CTCF ChIP-seq; FAIRE; TCGA transcriptomic analysis; ChIP-seq |
| Low Throughput Method: | CRISPR-Cas9 enhancer deletion; 3C assay; Luciferase reporter assay; ChIP-qPCR; qRT-PCR; Western blot; Colony formation assay; Xenograft tumor assay; CRISPR-Cas9 |
About Target Gene
| Target gene : | NTS |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer