About Enhancer
| Enhancer ID: | E_01453 |
| Species: | Homo sapiens |
| Position : | chr13:40800476-40817024   |
| Year: | 2020 |
| Title: | Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | alveolar rhabdomyosarcoma |
| PMID: | 32416589 |
| MONDO: | MONDO:0009994 |
| Cell Source: | Rh4 |
| CVCL ID: | CVCL_5916 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Chromatin interaction assay; Functional perturbation assay; Chromatin-state profiling |
| High Throughput Method: | ChIP-seq; ChIP-Rx; RNA-seq; 4C-seq; H3K27ac HiChIP; pooled CRISPR screen; HiChIP |
| Low Throughput Method: | Individual CRISPR-Cas9 enhancer perturbation; 3C PCR; RT-qPCR; Western blot; Sanger sequencing; ChIP |
About Target Gene
| Target gene : | PAX3::FOXO1 |
About TF
| TF name : | MYOD1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYOD1 | C-MYB transcription factor network | pid | 87 |
| MYOD1 | CDO in myogenesis | reactome | 29 |
| MYOD1 | ID | netpath | 38 |
| MYOD1 | Notch-mediated HES/HEY network | pid | 48 |
| MYOD1 | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| MYOD1 | Regulation of retinoblastoma protein | pid | 67 |
| MYOD1 | Signaling events mediated by HDAC Class III | pid | 41 |
| MYOD1 | Hs_ID_signaling_pathway_WP53_67360 | wikipathways | 8 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer