About Enhancer
| Enhancer ID: | E_01451 |
| Species: | Homo sapiens |
| Position : | chr6:32571777-32578269   |
| Year: | 2020 |
| Title: | A super enhancer controls expression and chromatin architecture within the MHC class II locus. |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Burkitt lymphoma |
| PMID: | 31753848 |
| MONDO: | MONDO:0007243 |
| Tissue: | blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Raji |
| CVCL ID: | CVCL_0511 |
| Cell Type: | B lymphocyte |
| Experiment Type: | Enhancer functional perturbation; chromatin interaction assay |
| High Throughput Method: | CIITA ChIP-seq; H3K27ac ChIP-seq; RNA-seq |
| Low Throughput Method: | CRISPR-Cas9 deletion; RT-qPCR; 3C; flow cytometry; CRISPR-Cas9 |
About Target Gene
| Target gene : | HLA-DQB1 |
About TF
| TF name : | CIITA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CIITA | Interferon gamma signaling | reactome | 88 |
| CIITA | Antigen processing and presentation | kegg | 75 |
| CIITA | Toxoplasmosis | kegg | 131 |
| CIITA | Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168 | wikipathways | 10 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01450 | chr6:32571777-32578269 | blood | B lymphocyte | Burkitt lymphoma |
Expression of Target Genes for the Enhancer