About Enhancer
| Enhancer ID: | E_01448 |
| Species: | Homo sapiens |
| Position : | chr3:36999364-37001216   |
| Year: | 2018 |
| Title: | Disruption of a -35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal carcinoma |
| PMID: | 29898989 |
| MONDO: | MONDO:0024331 |
| Tissue: | colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | SW620 |
| CVCL ID: | CVCL_0547 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Functional perturbation assay, Chromatin interaction assay; Enhancer activity assay; Endogenous enhancer perturbation; Chromatin interaction assay; Disease-variant functional analysis |
| High Throughput Method: | ChIA-PET, RNA-seq; CRISPR genetic screen |
| Low Throughput Method: | qRT-PCR, and ChIP-qPCR; CRISPR-Cas9 endogenous deletion/editing; Luciferase reporter assay; ChIP; 3C; Reporter assay |
About Target Gene
| Target gene : | MLH1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01459 | chr3:36999364-37001216 | colon | NA | Lynch Syndrome |
Expression of Target Genes for the Enhancer