About Enhancer
| Enhancer ID: | E_01443 |
| Species: | Homo sapiens |
| Position : | chr20:50030216-50034271   |
| Year: | 2025 |
| Title: | Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity. |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Breast cancer cell plasticity / epithelial-mesenchymal transition |
| PMID: | 40133308 |
| MONDO: | MONDO:0007254 |
| Tissue: | breast epithelium |
| Tissue Ontology ID: | UBERON:0008367 |
| Cell Source: | MCF10AT1k.cl2 and breast-cancer epithelial models |
| CVCL ID: | CVCL_WM98 |
| Cell Type: | mammary epithelial cell / transformed epithelial cell |
| Cell Ontology ID: | CL:0002327 |
| Experiment Type: | Enhancer-RNA-producing SNAI1 regulatory locus; cis eRNA perturbation; cancer-cell plasticity validation |
| High Throughput Method: | Not a high-throughput enhancer-discovery study; enhancer/eRNA locus supported by transcriptomic and chromatin-regulatory analyses reported in the study |
| Low Throughput Method: | GapmeR eRNA knockdown; CRISPRa; RT-qPCR; Western blot; BRD4 recruitment assays; EMT, migration, stemness and drug-response phenotyping |
About Target Gene
| Target gene : | SNAI1 |
About TF
| TF name : | NA |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer