About Enhancer
| Enhancer ID: | E_01383 |
| Species: | Homo sapiens |
| Position : | chr3:128322411-128323124   |
| Year: | 2021 |
| Title: | Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia. |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 33980539 |
| MONDO: | MONDO:0018874 |
| Tissue: | bone marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | MUTZ-3 |
| CVCL ID: | CVCL_1433 |
| Cell Type: | malignant cell |
| Cell Ontology ID: | CL:0001064 |
| Experiment Type: | Enhancer essentiality assay; TF binding assay; Functional perturbation assay; Target-gene expression assay |
| High Throughput Method: | Genome-wide CRISPR/Cas9 enhancer scan; ATAC-seq; H3K27ac ChIP-seq; p300 ChIP-seq; MYB ChIP-seq; CUT&RUN; deep amplicon sequencing |
| Low Throughput Method: | CRISPR/Cas9 MYB-motif mutagenesis; MYB knockout; MYBMIM-mediated MYB-CBP/p300 inhibition; RT-qPCR; Western blot; flow cytometry; differentiation and cell-viability assays |
About Target Gene
| Target gene : | MECOM |
About TF
| TF name : | MYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYB | AP-1 transcription factor network | pid | 71 |
| MYB | C-MYB transcription factor network | pid | 87 |
| MYB | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| MYB | IL2 signaling events mediated by PI3K | pid | 38 |
| MYB | IL4-mediated signaling events | pid | 66 |
| MYB | Notch-mediated HES/HEY network | pid | 48 |
| MYB | Prolactin | netpath | 105 |
| MYB | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
41 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_03426 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03427 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03428 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03429 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03430 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03431 | chr3:128322357-128323157 | bone marrow | malignant cell | acute myeloid leukemia with inv(3)/t(3; 3); MECOM-rearranged AML |
| E_03504 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03505 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03506 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03507 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03508 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03509 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03510 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03511 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03512 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03513 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03514 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03515 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03516 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03517 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03518 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03519 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03520 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03521 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03522 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03523 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_03524 | chr3:128322357-128323157 | bone marrow | malignant cell | MECOM-rearranged acute myeloid leukemia |
| E_01351 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [inv(3)(q21;q26.2)/t(3;3)(q21;q26.2)] |
| E_01372 | chr3:128322411-128323124 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01373 | chr3:128322411-128323124 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01382 | chr3:128322411-128323124 | peripheral blood | AML hematopoietic progenitor-like leukemia cell | acute myeloid leukemia |
| E_01394 | chr3:128322411-128323124 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01395 | chr3:128322411-128323124 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01396 | chr3:128322411-128323124 | bone marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_01397 | chr3:128322411-128323124 | blood | myeloid leukemia cell | acute myeloid leukemia |
| E_01403 | chr3:128322411-128323124 | peripheral blood | AML hematopoietic progenitor-like leukemia cell | acute myeloid leukemia |
| E_01404 | chr3:128322411-128323124 | peripheral blood | AML hematopoietic progenitor-like leukemia cell | acute myeloid leukemia |
| E_03530 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
| E_03531 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
| E_03532 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
| E_03533 | chr3:128322411-128323124 | Bone marrow / hematopoietic system | myeloid leukemia cell | Acute myeloid leukemia with MECOM rearrangement [3q-AML] |
Expression of Target Genes for the Enhancer